Watching Proteins Fold with Transient Laser Spectroscopy
The processes by which a protein's amino acid sequence forms a unique three-dimensional structure remains one of the most challenging issues in fundamental and applied biomolecular science. Studies of this biological problem are complicated by the need to study dynamical behavior involving small populations of transient species in a solution environment. However, the use of advanced transient laser spectroscopy techniques based on intrinsic chromophores provides a powerful means to study this problem.
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