Cutting Tissue With Ultrashort Pulsed Laser Light

Philbert S. Tsai, Beth Friedman, Jeffrey Squier and David Kleinfeld

Ultrashort pulsed laser light can be used to cut biological tissue in a highly localized and controlled manner. Among the practical applications that are beginning to emerge: an all-optical technique for automated, three-dimensional histology of brain tissue and an optical-based technique to incorporate plasmid DNA into living cells.

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