Micron Resolution Biomedical Imaging With Optical Coherence Tomography

Joseph A. Izatt, Michael R. Hee, David Huang, Eric A. Swanson, Charles P. Lin, Joel S. Schuman, Carmen A. Puliafito and James G. Fujimoto

In recent years, a number of powerful techniques have been developed for noninvasive biomedical imaging, including ultrasound, x-ray computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET). Each of these methods has different advantages and limitations for particular clinical applications. Optical imaging of tissue offers the potential of a noninvasive, high resolution diagnostic using non-ionizing radiation, and the possibility of using spectroscopic properties to distinguish tissue type and probe metabolic function. Recent advances in optics and photonics technology, including semiconductor lasers, fiber optics, and high quantum efficiency solid state detectors, suggest the possibility of a clinically viable optical biomedical imaging technology.

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