Scatterings
Watching Molecular Machines Splice RNA
A recent paper in Science describes how this unusual combination of methods allows researchers to study the assembly of a so-called “spliceosome” in real time.
A multiple-wavelength microscope system is designed to excite fluorescing biomolecules, allowing researchers to watch the assembly of RNA.
Multiwavelength single-molecule fluorescence microscopy, combined with genetic engineering and chemical biology techniques, allows unprecedented imaging of the splicing of RNA molecules by a complex molecular machine. A recent paper in Science describes how this unusual combination of methods allows researchers to study the assembly of a so-called “spliceosome” in real time (A.A. Hoskins et al., doi: 10.1126/science.1198830).
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